1 Suarez FL, Levitt DL. In :Feldman M, Friedman LS, Sleisenger MH, eds. Gastrointestinal and Liver Disease : pathology, diagnosis, management. 7 th ed. Philadephia : Saunders, 2002 ; 155-63.
2 Azpiroz F, Malagelada JR. Abdominal bloating. Gastroenterology 2005 ; 129 : 1060-78.
3Chang L, Lee OY, Naliboff B, et al. Sensation of bloating and visible abdominal distention in patients with irritable bowel syndrome. Am J Gastroenterol 2001 ; 96 : 3341-47.
4 Sandler RS, Stewart WF, Liberman JN, et al. Abdominal pain, bloating, and diarrhea in the United States : prevalence and impact. Dig Dis Sci 2000 ; 45 : 1166-71.
5Serra J, Azpiroz F, Malagelada JR. Intestinal gas dynamics and tolerance in humans. Gastroenterology 1998 ; 115 : 542-50.
6 Salvioli B, Serra J, Azpiroz F et, al. Origin of gas retention and symptoms in patients with bloating. Gastroenterology 2005 ; 128 : 574-9.
7Harder H, Serra J, Azpiroz F, et al. Intestinal gas distribution determines abdominal symptoms. Gut 2003 ; 52 : 1708-13.
8 Serra J. Gaz digestifs et motricité. Hepatogastro 2006 ; 13 : 39-41.
9Levitt MD, Furne J, Aerolus MR, et al. Evaluation of an extremely flatutent patient, cas report and proposed diagnostic and therapeutic approch. Am J Gastroenterol 1998 ; 93 : 2276-81.
10Rao SS. Belching, bloating, and flatulence. How to help patients who have troublesome abdominal gas. Postgrad Med 1997 ; 101 : 263-9, 275-8.
11Zar S, Benson MJ, Kumar D. Review article : bloating in functionnal bowel disorders. Aliment Pharmacol Ther 2002 ; 16 : 1867-76.
12Salvioli B, Serra J, Azpiroz F, et al. Origin of gas retention and symptoms in patients with bloating. Gastroenterology 2005 ; 128 : 574-79.
13Sandler RS, Stewart WF, Liberman JN, et al. Abdominal pain, bloating, and diarrhea in the United States : prevalence and impact. Dig Dis Sci 2000 ; 45 : 1166-71.
14Levitt MD. Volume and composition of human intestinal gas determined by means of a intestinal washout technic. N Eng J Med 1971 ; 284 : 1394-98.
15Levitt MD, lasser Rb, Schwartz JS, et al. Studies of a flatulent patient. N Eng J Med 1976 ; 295 : 260-2.
16 Lasser RB, Bond JH, Levitt MD. The role of intestinal gas in functionnal abdominal pain. N Eng J Med 1975 ; 293 : 524-6.
17Maxton DG, Martin DF,Whorwell PJ, et al. Abdominal distention in femal patients with irritable bowel syndrome : exploration of possible mechanisms. Gut 1991 : 32 : 662-4.
18Alvarez W. Hysterical type of nongaseous abdominal bloating. Arch Intern Med 1949 ; 84 : 217-45.
19 Maxton DG, Whorwell PJ. Abdominal distension in irritable bowel syndrome: the patient’s perception. Eur J Gastroenterol Hepatol 1992 ; 4 : 241-43.
20McManis PG, Newall D, Talley NJ. Abdominal wall muscle activity in irritable bowel syndrome with bloating. Am J Gastroenterol 2001 ; 96 : 1139-42.
21Tremolaterra F, Villoria A, Azpiroz F, et al. Impaired viscerosomatic reflexes abdominal-wall dystony associated with bloating. Gastroenterology 2006 ; 130 : 1062-68.
22Caldarella MP, Serra J, Azpiroz F, et al. Prokinetic effects of neostigmine in patients with intestinal gas retention. Gastroenterology 2002 ; 122 : 1748-1755.
23Serra J, Salvioli B, Azpiroz F, et al. Lipid-induced intestinal gas retention in the irritable bowel syndrome. Gastroenterology 2002 ; 123 : 700-706.
24Serra J, Azpiroz F, Malagelada JR. Mechanisms of intestinal gas retention in humans : impaired propulsion versus obstructed evacuation. Am J Physiol Gastrointest Liver Physiol 2001 ; 281 : G138-G143.
25Bouin M, Lupien F, Riberdy M, et al. Intolerance to visceral distension in functional dyspepsia or irritable bowel syndrome : an organ specific defect or a pan intestinal dysregulation ?. Neurogastroenterol Motil 2004 ; 16 : 311-14.
26Accarino AM, Azpiroz F, Malagelada J-R. Selective dysfunction of mechanosensitive intestinal afferents in the irritable bowel syndrome. Gastroenterology 1995 ; 108 : 636-43.
27Coffin B, Azpiroz F, Guarner F et al. Selective gastric hypersensitivity and reflex hyporeactivity in functional dyspepsia. Gastroenterology 1994 ; 107 : 1345-51.
28Caldarella M, Azpiroz F, Malagelada J-R. Antro-fundic dysfunctions in functional dyspepsia. Gastroenterology 2003 ; 124 : 1220-29.
29 Lea R, Whorwell P, Reilly B, et al. Abdominal distension in irritable bowel syndrome (IBS) : diurnal variation and its relationship to abdominal bloating. (abstr) Gut 2003 ; 52 : A32.
30Heitkemper MM, Cain KC, Jarrett ME, et al. Relationship of bloating to other GI and menstrual symptoms in women with irritable bowel syndrome. Dig Dis Sci 2004 ; 49 : 88-95.
31Lembo T, Naliboff B, Munakata J, et al. Symptoms and visceral perception in patients with pain-predominant irritable bowel syndrome. Am J Gastroenterol 1999 ; 94 : 1320-26.
32Sach J, Bolus R, Fitzgerald L, et al. Is there a difference between abdominal pain and discomfort in moderate to severe IBS patients ?. Am J Gastroenterol 2002 ; 12 : 3131-38.
33Wiklund IK, Fullerton S, Hawkey CJ,et al. An irritable bowel syndrome-specific symptom questionnaire : development and validation. Scand Gastroenterol 2003 ; 38 : 947-54.
34Marcus SN, Heaton KW. Irritable bowel-type symptoms in spontaneous and induced constipation. Gut 1987 ; 28 : 156-59.
35 Mertz H, Naliboff B, Mayer EA. Symptoms and physiology in severe chronic constipation. Am J Gastroenterol 1999 ; 94 : 131-38.
36Lea R, Houghton LA, Whorwell PJ et al. Relationship of abdominal bloating to physical distension in irritable bowel syndrome (IBS): effect of bowel habit. (abstr) Neurogastroenterol Motil 2003 ; 15 : 587.
37 Lasser RB, Levitt MD, Bond JH. Studies of intestinal gas after ingestion of a standard meal. (abstr) Gastroenterology 1976 ; 70 : A906.
38Wolever TM, Robb PA. Effect of guar, pectin, psyllium, soy polysaccharide, and cellulose on breath hydrogen and methane in healthy subjects. Am J Gastroenterol 1992 ; 87 : 305-10.
39Grimble G. Fibre, fermentation, flora, and flatus. Gut 1989 ; 30 : 6-13.
40Anderson IH, Levine AS, Levitt MD. Incomplete absorption of the carbohydrate in all-purpose wheat flour. N Engl J Med 1981 ; 304 : 891-92.
41Steggerda FR. Gastrointestinal gas following food consumption. Ann N Y Acad Sci 1968 ; 150 : 57-66.
42Rumessen JJ, Gudmand-Hoyer E. Functional bowel disease : malabsorption and abdominal distress after ingestion of fructose, sorbitol, and fructose-sorbitol mixtures. Gastroenterology 1988 ; 95 : 694-700.
43Fernandez-Banares F, Esteve-Pardo M, de Leon R, et al. Sugar malabsorption in functional bowel disease : clinical implications. Am J Gastroenterol 1993 ; 88 : 2044-50.
44Symons P, Jones MP, Kellow JE. Symptom provocation in irritable bowel syndrome. Effects of differing doses of fructose-sorbitol. Scand J Gastroenterol 1992 ; 27 : 940-44.
45Afdhal NH, Piggott C, Long AA, et al.. Carbohydrate handling by colonic flora—is it pathogenic in the irritable bowel syndrome ?. Ir J Med Sci 1986 ; 155 : 197-201.
46Nelis GF, Vermeeren MA, Jansen W. Role of fructose-sorbitol malabsorption in the irritable bowel syndrome. Gastroenterology 1990;99:1016-20.
47McKee AM, Prior A, Whorwell PJ. Exclusion diets in irritable bowel syndrome: are they worthwhile?. J Clin Gastroenterol 1987;9:526-28.
48Serra J, Azpiroz F, Malagelada JR. Impared transit and tolerance of intestinal gas in irritable bowel syndrome. Gut 2001 ;48 :14-9.
49King TS, Elia M, Hunter JO. Abnormal colonic fermentation in irritable bowel syndrome. Lancet 1998;352:1187-1189.
50Haderstorfer B, Whitehead WE, Schuster MM. Intestinal gas production from bacterial fermentation of undigested carbohydrate in irritable bowel syndrome. Am J Gastroenterol 1989;84:375-78.
51Pimentel M, Chow EJ, Lin HC. Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. A double-blind, randomized, placebo-controlled study. Am J Gastroenterol 2003;98:412-19.
52Azpiroz F. Gastrointestinal perception: pathophysiological implications. Neurogastroenterol Motil 2002;14:1-11.
53Hamberg O, Rumessen JJ, Gudmand-Hoyer E. Inhibition of starch absorption by dietary fibre. A comparative study of wheat bran, sugar-beet fibre, and pea fibre. Scand J Gastroenterol 1989 ; 24 : 103-9.
54Brugge WR, Rosenfeld MS. Impairment of starch absorption by a potent amylase inhibitor. Am J Gastroenterol 1987 ; 82 : 718-22.
55 Taylor RH, Barker HM, Bowey EA, et al. Regulation of the absorption of dietary carbohydrate in man by two new glycosidase inhibitors. Gut 1986 ; 27 : 1471-78.
56Layer P, Zinsmeister AR, DiMagno EP. Effects of decreasing intraluminal amylase activity on starch digestion and postprandial gastrointestinal function in humans. Gastroenterology 1986 ; 91 : 41-8.
57Madden JA, Hunter JO. A review of the role of the gut microflora in irritable bowel syndrome and the effects of probiotics. Br J Nutr 2002 ; 88 : S67-S72.
58 Hamilton-Miller JMT. Probiotics in the management of irritable bowel syndrome: a review of clinical trials. Microb Ecol Health Dis 2001 ; 13 : 212-216.
59Lea R, Houghton LA, Calvert EL, Larder S, et al. Gut-focused hypnotherapy normalizes disordered rectal sensitivity in patients with irritable bowel syndrome. Aliment Pharmacol Ther 2003 ; 17 : 635-42.
60Whorwell PJ, Hoghton LA, Taylor EE, et al. Physiological effects of emotion : a study via hypnosis. Lancet 1992 ; 340 : 69-72.
61Azpiroz F, Enck P, Whitehead WE. Anorectal functional testing. Review of a collective experience. Am J Gastroenterol 2002 ; 97 : 232-40.
62Whitehead WE, Wald A, Diamant N, Enck P, et al. Functional disorders of the anus and rectum. In The functional gastrointestinal disorders. Rome II, 2nd ed., eds D.A. Drossman, E. Corazziari, N. Talley, W.G. Thompson, W.E. Whitehead. McLean, VA : Degnon Associates ; 2000. p. 483-32.
63Levitt MD, Furne J, Olsson S. The relation of passage of gas and abdominal bloating to colonic gas production. Ann Intern Med 1996 ; 124 : 422-24.
64 Hebden JM, Blackshaw E, D’Amato M, et al. Abnormalities of GI transit in bloated irritable bowel syndrome : effect of bran on transit and symptoms. Am J Gastroenterol 2002 ; 97 : 2315-20.
65Sullivan SN. A prospective study of unexplained visible abdominal bloating. N Z Med J 1994 ; 1 : 428-430.
66Dainese R, Serra J, Azpiroz F, et al. Influence of body posture on intestinal transit of gas. Gut 2003 ; 52 : 971-74.
67Dainese R, Serra J, Azpiroz F, et al. Effect of physical activity on intestinal gas transit and evacuation in healthy subject. Am J Med 2004 ; 116 : 536-39.
68Metcalf TJ, Irons TG, Sher LD,et al. Simethicone in the treatment of infant colic : a randomized, placebo-controlled, multicenter trial. Pediatrics 1994 ; 94 : 29-34.
69Holtmann G, Gschossmann J, Mayr P, et al. A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia. Aliment Pharmacol Ther 2002 ; 16 : 1641-48.
70Suarez FL, Furne J, Springfield J, et al. Failure of activated charcoal to reduce the release of gases produced by the colonic flora. Am J Gastroenterol 1999 ; 94 : 208-212.
71Suarez F, Levitt MD, Adsheat J, et al. Pancreatic supplements reduce symptomatic response of healthy subjects to a high fat meal. Dig Dis Sci 1999 ; 44 : 1317-1321.
72Poynard T, Regimbeau C, Benhamou Y. Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 2001 ; 15 : 355-361.
73Sharana AL, Abdukl Baki H et al. A randomized double-blind placebo-controlled trial of rifaximin in patients with abdominal bloating and flatulence. Am J Gastroenterol 2006 ; 101 : 326-33.
74Evans BW, Clark WK, Moore DJ, Whorwell PJ. Tegaserod for the treatment of irritable bowel syndrome. Cochrane Database Syst Rev 2004(1) : CD003960.